Mouse Genome Informatics
ht
    Fgfr3tm1.1Aomw/Fgfr3+
CBA/Ca.129P2-Fgfr3tm1.1Aomw
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
craniofacial
N
• no heterozygotes with craniofacial abnormalities were found (J:143356)
• Background Sensitivity: craniofacial abnormalities are less severe on a congenic CBA/Ca background compared to mice on 129S6/SvEvTac background but more severe compared to mice on a BALB/c, congenic background (J:144356)
• only males develop craniofacial abnormalities (J:144356)
• a few mice have rounded skulls
• seen in a few mice
• a few mice have a shortened and often twisted snout

hearing/vestibular/ear
• increased ABR threshold at all test frequencies except 33 kHz
• hearing loss is more severe in homozygotes compared to heterozygotes
• hearing loss is less severe at 32 kHz than at lower frequencies
• Background Sensitivity: hearing loss is less severe in mice on a CBA/Ca congenic background compared to mice on a congenic 129S6/SvEvTac or C57BL/6 background

skeleton
• a few mice have rounded skulls
• seen in a few mice

growth/size
• a few mice have a shortened and often twisted snout

Mouse Models of Human Disease
OMIM IDRef(s)
Muenke Syndrome; MNKES 602849 J:144356