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Phenotypes Associated with This Genotype
Genotype
MGI:3831281
Allelic
Composition		 Trp53tm1Brn/Trp53tm1Brn
Tg(GFAP-cre)25Mes/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(GFAP-cre)25Mes mutation (2 available)
Trp53tm1Brn mutation (20 available); any Trp53 mutation (236 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased astrocytoma incidence ( J:140704 )
• 4 of 23 mice develop anaplastic astrocytomas

nervous system
increased astrocytoma incidence ( J:140704 )
• 4 of 23 mice develop anaplastic astrocytomas

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory