Phenotypes Associated with This Genotype

Genotype
MGI:3831280

• Allelic Composition: Pten^tm1Rdp/Pten⁺; Trp53^tm1Brn/Trp53^tm1Brn; Tg(GFAP-cre)25Mes/0
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

ataxia ( J:140704 )

• in 73% of mice at 15 to 40 weeks of age

paralysis ( J:140704 )

• in 73% of mice at 15 to 40 weeks of age

seizures ( J:140704 )

• in 73% of mice at 15 to 40 weeks of age

neoplasm

increased glioma incidence ( J:140704 )

• 73% of mice develop malignant gliomas consisting of anaplastic astrocytomas (in 66% of mice with tumors) and glioblastomas (in 34% of mice with tumors)

increased glioblastoma incidence ( J:140704 )

• 34% of mice with tumors develop glioblastomas

increased astrocytoma incidence ( J:140704 )

• anaplastic astrocytomas (in 66% of mice with tumors)

nervous system

seizures ( J:140704 )

• in 73% of mice at 15 to 40 weeks of age

increased glioma incidence ( J:140704 )

• 73% of mice develop malignant gliomas consisting of anaplastic astrocytomas (in 66% of mice with tumors) and glioblastomas (in 34% of mice with tumors)

increased glioblastoma incidence ( J:140704 )

• 34% of mice with tumors develop glioblastomas

increased astrocytoma incidence ( J:140704 )

• anaplastic astrocytomas (in 66% of mice with tumors)