Phenotypes Associated with This Genotype

Genotype
MGI:3831189

• Allelic Composition: Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺; Wnt7a^tm1Amc/Wnt7a^tm1Amc; Wnt7b^tm1Parr/Wnt7b^tm2Amc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:142352 )

• all embryos die around E12.5 due to severe hemorrhaging within the central nervous system

cardiovascular system

abnormal vasculogenesis ( J:142352 )

• while vascularization has occurred within the ventral neural tube of control E10.5 embryos at the forelimb level, no such vascularization is observed in this region of mutant embryos

• in E12.5 embryos, endothelial cells and pericytes are absent from all ventral neural regions of the presumptive spinal cord except for in the floor plate

• in the dorsal neural tube of E12.5 embryos, endothelial cells and pericytes form abnormal clusters and enlarged lumens in the vascular structures present

intracranial hemorrhage ( J:142352 )

• hemorrhaging is detected throughout the developing brain of E12.5 embryos

spinal hemorrhage ( J:142352 )

• hemorrhaging is detected throughout the developing spine of E12.5 embryos

abnormal blood-brain barrier function ( J:142352 )

• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos

nervous system

intracranial hemorrhage ( J:142352 )

• hemorrhaging is detected throughout the developing brain of E12.5 embryos

spinal hemorrhage ( J:142352 )

• hemorrhaging is detected throughout the developing spine of E12.5 embryos

abnormal blood-brain barrier function ( J:142352 )

• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos