Phenotypes Associated with This Genotype

Genotype
MGI:3831181

• Allelic Composition: Lig4^tm1Icrf/Lig4^tm1Icrf; Mre11a^tm1Jpt/Mre11a^tm1Jpt
• Genetic Background: involves: 129 * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:144172 )

• survived to birth but died thereafter

cellular

decreased cellular sensitivity to ionizing radiation induced cell death ( J:144172 )

• ionizing radiation-induced apoptosis in the developing nervous system is almost completely blocked

• mice exhibit reduced ionizing radiation-induced apoptosis in the telencephalon, metencephalon, spinal cord, and dorsal root ganglia compared to in wild-type mice

homeostasis/metabolism

decreased cellular sensitivity to ionizing radiation induced cell death ( J:144172 )

• ionizing radiation-induced apoptosis in the developing nervous system is almost completely blocked

• mice exhibit reduced ionizing radiation-induced apoptosis in the telencephalon, metencephalon, spinal cord, and dorsal root ganglia compared to in wild-type mice