Phenotypes for Lig4 Mre11a MGI:3831181 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Lig4^tm1Icrf/Lig4^tm1Icrf Mre11a^tm1Jpt/Mre11a^tm1Jpt
Genetic Background	involves: 129 * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4^tm1Icrf mutation (0 available); any Lig4 mutation (44 available)
Mre11a^tm1Jpt mutation (1 available); any Mre11a mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:144172 )

• survived to birth but died thereafter

cellular

decreased cellular sensitivity to ionizing radiation ( J:144172 )

• ionizing radiation-induced apoptosis in the developing nervous system is almost completely blocked

• mice exhibit reduced ionizing radiation-induced apoptosis in the telencephalon, metencephalon, spinal cord, and dorsal root ganglia compared to in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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