Phenotypes Associated with This Genotype

Genotype
MGI:3831180

• Allelic Composition: Mre11a^tm1Jpt/Mre11a^tm1Jpt
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased cellular sensitivity to ionizing radiation ( J:144172 )

• at E13.5, E15.5, and P5, mice exhibit resistance to ionizing radiation-induced apoptosis in the retina and dentate gyrus compared to wild-type mice

• ionizing radiation-induced apoptosis in the thymus is reduced compared to in wild-type mice

• however, ionizing radiation-induced apoptosis in the proliferating embryonic ventricular zone is normal