Analysis Tools
nervous system
| N |
• mice exhibit normal gross brain morphology
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• mice exhibit reduced NMDA-induced neurotoxicity compared to wild-type mice
• however, this attenuation can be reversed by co-treatment with D-serine
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• mice exhibit reduced neuronal damage in response to beta-amyloid peptide 1-42 compared to similarly treated wild-type mice
• however, co-treatment with an NMDA receptor antagonist reverses this protection
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homeostasis/metabolism
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• mice exhibit reduced NMDA-induced neurotoxicity compared to wild-type mice
• however, this attenuation can be reversed by co-treatment with D-serine
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• levels of D-serine in the cerebral cortex and hippocampus are 10-fold less than in wild-type mice
• however, mice exhibit normal levels of L-serine, glycine and glutamate
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cellular
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• mice exhibit reduced NMDA-induced neurotoxicity compared to wild-type mice
• however, this attenuation can be reversed by co-treatment with D-serine
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