Phenotypes Associated with This Genotype

Genotype
MGI:3830834

• Allelic Composition: Rhoh^tm1Hasu/Rhoh^tm1Hasu
• Genetic Background: B6.Cg-Rhoh^tm1Hasu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:143491 )

N • despite impaired anaphylaxis, mice exhibit normal mast cell development

abnormal mast cell physiology ( J:143491 )

• calcium concentrations in antigen-challenged bone marrow-derived mast cells is less than in wild-type cells

decreased mast cell degranulation ( J:143491 )

• when challenged with DNP-HAS, mice exhibit reduced histamine secretion compared to similarly treated wild-type mice

• bone marrow-derived mast cells exhibit reduced antigen to IgE antibody mediated cross-linking compared to wild-type cells

decreased susceptibility to type I hypersensitivity reaction ( J:143491 )

• in an assay for IgE-dependent passive systemic anaphylaxis using DNP-HSA, mice exhibit a smaller decrease in core body temperature and reduced histamine secretion compared to similarly treated wild-type mice

hematopoietic system

abnormal mast cell physiology ( J:143491 )

• calcium concentrations in antigen-challenged bone marrow-derived mast cells is less than in wild-type cells

decreased mast cell degranulation ( J:143491 )

• when challenged with DNP-HAS, mice exhibit reduced histamine secretion compared to similarly treated wild-type mice

• bone marrow-derived mast cells exhibit reduced antigen to IgE antibody mediated cross-linking compared to wild-type cells

cellular

decreased mast cell degranulation ( J:143491 )

• when challenged with DNP-HAS, mice exhibit reduced histamine secretion compared to similarly treated wild-type mice

• bone marrow-derived mast cells exhibit reduced antigen to IgE antibody mediated cross-linking compared to wild-type cells