Phenotypes Associated with This Genotype

Genotype
MGI:3830816

• Allelic Composition: Gsk3b^tm1.1Atak/Gsk3b⁺
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:144055 )

N • despite impaired spatial reference memory, mice exhibit normal motor and emotional behaviors

abnormal learning/memory/conditioning ( J:144055 )

• in contextual conditioning assay and Morris water maze assay, mice fail to achieve reconsolidation when memory is reactivated once before testing unlike in wild-type mice

abnormal contextual conditioning behavior ( J:144055 )

• mice exhibit retrograde amnesia in contextual conditioning assay with repeated conditioning unlike wild-type mice

abnormal spatial reference memory ( J:144055 )

• mice exhibit retrograde amnesia with repeated training in a Morris water maze unlike wild-type mice

homeostasis/metabolism

abnormal bone healing ( J:211406 )

• acceleration of bone regeneration following bone injury

• density of regenerated bones following injury is higher than in wild-type mice

skeleton

abnormal bone healing ( J:211406 )

• acceleration of bone regeneration following bone injury

• density of regenerated bones following injury is higher than in wild-type mice

increased compact bone volume ( J:211406 )

increased trabecular bone volume ( J:211406 )

abnormal skeleton development ( J:211406 )

• enhanced bone development, of both cortical and trabecular bone and after injury