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Phenotypes Associated with This Genotype
Genotype
MGI:3830712
Allelic
Composition		 Dock2m1Hsd/Dock2m1Hsd
Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic
Background		 B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock2m1Hsd mutation (0 available); any Dock2 mutation (143 available)
Siaetm1.2Avrk mutation (0 available); any Siae mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Glomerulonephritis in Siaetm1.2Avrk/Siaetm1.2Avrk mice

immune system
decreased B-1a cell number ( J:144035 )
• the percentage of B1a B cells in the peritoneum is reduced by about half
decreased follicular B cell number ( J:144035 )
• there is a selective loss of recirculating follicular phenotype B cells from the perisinusoidal niche of bone marrow
decreased marginal zone B cell number ( J:144035 , J:231437 )
• numbers of IgMhiIgDhiCD21hiMZ B cell precursors (MZP), as well as IgMhiIgDlowCD21hiMZ B cells, are severely reduced in the spleen compared to controls (J:144035)
• MZP B cells are reduced 10.5 fold and MZ B cells are reduced 23 fold compared to controls (J:144035)
• Background Sensitivity: unlike mice bred to a C57BL/6J background for an additional 13 generation, mice bred to a C57BL/6NHsd background for only 10 generations exhibit loss of marginal zone B cells compared with wild-type mice (J:231437)
increased B-1b cell number ( J:144035 )
• the percentage of B1b B cells in the peritoneum is increased by over half
increased CD4-positive, alpha-beta memory T cell number ( J:231437 )
• Background Sensitivity: unlike mice bred to a C57BL/6J background for an additional 13 generation, mice bred to a C57BL/6NHsd background for only 10 generations exhibit an increase in memory T cells in blood and spleen compared with wild-type mice
decreased T cell number ( J:144035 )
• T cell numbers are slightly reduced in the thymus and almost 2-fold reduced in the spleen
spleen hypoplasia ( J:144035 )
• there is a 2.4 fold decrease in the number of cells in the spleen compared to controls
abnormal B cell activation ( J:144035 )
• splenic B cells stimulated with anti-IgM have enhanced calcium influx
• enhanced calcium influx was observed for newly formed B cells, follicular B cells, and marginal zone B cells
increased B cell proliferation ( J:144035 )
• B cells proliferate faster than controls with sub-optimal doses of anti-IgM
• the proliferation advantage is diminished with higher doses and/or longer stimulation times possibly from increased rates of apoptosis
increased IgE level ( J:144035 )
• IgE levels are significantly higher than in controls
increased IgG1 level ( J:144035 )
• IgG1 levels are significantly higher than in controls
increased IgG2a level ( J:144035 )
• lower levels of antigen-specific IgG2a are present after immunization
increased IgG2b level ( J:144035 )
• IgG2b levels are significantly higher than in controls
• however, lower levels of antigen-specific IgG2b are present after immunization
increased IgG3 level ( J:144035 )
• lower levels of antigen-specific IgG3 are present after immunization
increased IgM level ( J:144035 )
• IgM levels are significantly higher than in controls
increased anti-double stranded DNA antibody level ( J:144035 )
• higher levels of anti-DS DNA antibodies than in controls are found in the sera of mice 20-60 weeks of age
increased anti-histone antibody level ( J:144035 )
• higher levels of anti-histone antibodies than in controls are found in the sera of mice 20-60 weeks of age
increased anti-single stranded DNA antibody level ( J:144035 )
• higher levels of anti-SS DNA antibodies than in controls are found in the sera of mice 20-60 weeks of age
glomerulonephritis ( J:144035 )
• mutants develop an immune complex-glomerulonephritis

hematopoietic system
decreased B-1a cell number ( J:144035 )
• the percentage of B1a B cells in the peritoneum is reduced by about half
decreased follicular B cell number ( J:144035 )
• there is a selective loss of recirculating follicular phenotype B cells from the perisinusoidal niche of bone marrow
decreased marginal zone B cell number ( J:144035 , J:231437 )
• numbers of IgMhiIgDhiCD21hiMZ B cell precursors (MZP), as well as IgMhiIgDlowCD21hiMZ B cells, are severely reduced in the spleen compared to controls (J:144035)
• MZP B cells are reduced 10.5 fold and MZ B cells are reduced 23 fold compared to controls (J:144035)
• Background Sensitivity: unlike mice bred to a C57BL/6J background for an additional 13 generation, mice bred to a C57BL/6NHsd background for only 10 generations exhibit loss of marginal zone B cells compared with wild-type mice (J:231437)
increased B-1b cell number ( J:144035 )
• the percentage of B1b B cells in the peritoneum is increased by over half
increased CD4-positive, alpha-beta memory T cell number ( J:231437 )
• Background Sensitivity: unlike mice bred to a C57BL/6J background for an additional 13 generation, mice bred to a C57BL/6NHsd background for only 10 generations exhibit an increase in memory T cells in blood and spleen compared with wild-type mice
decreased T cell number ( J:144035 )
• T cell numbers are slightly reduced in the thymus and almost 2-fold reduced in the spleen
spleen hypoplasia ( J:144035 )
• there is a 2.4 fold decrease in the number of cells in the spleen compared to controls
abnormal B cell activation ( J:144035 )
• splenic B cells stimulated with anti-IgM have enhanced calcium influx
• enhanced calcium influx was observed for newly formed B cells, follicular B cells, and marginal zone B cells
increased B cell proliferation ( J:144035 )
• B cells proliferate faster than controls with sub-optimal doses of anti-IgM
• the proliferation advantage is diminished with higher doses and/or longer stimulation times possibly from increased rates of apoptosis
increased IgE level ( J:144035 )
• IgE levels are significantly higher than in controls
increased IgG1 level ( J:144035 )
• IgG1 levels are significantly higher than in controls
increased IgG2a level ( J:144035 )
• lower levels of antigen-specific IgG2a are present after immunization
increased IgG2b level ( J:144035 )
• IgG2b levels are significantly higher than in controls
• however, lower levels of antigen-specific IgG2b are present after immunization
increased IgG3 level ( J:144035 )
• lower levels of antigen-specific IgG3 are present after immunization
increased IgM level ( J:144035 )
• IgM levels are significantly higher than in controls

renal/urinary system
glomerulonephritis ( J:144035 )
• mutants develop an immune complex-glomerulonephritis

cellular
increased B cell proliferation ( J:144035 )
• B cells proliferate faster than controls with sub-optimal doses of anti-IgM
• the proliferation advantage is diminished with higher doses and/or longer stimulation times possibly from increased rates of apoptosis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory