Phenotypes Associated with This Genotype

Genotype
MGI:3830058

• Allelic Composition: Il17f^tm1Yiw/Il17f^tm1Yiw
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to bacterial infection ( J:143719 )

• a substantially greater number of bacteria are detected in the colon 7 to 21 days after oral infection with C. rodentium than in controls

• remarkable hypertrophy of the colon and spleen occurs after infection with C. rodentium

• C. rodentium infection leads to more severe histopathology of the colon, and significantly increases crypt length