Phenotypes Associated with This Genotype

Genotype
MGI:3829752

• Allelic Composition: Rptor^tm1Rueg/Rptor^tm1Rueg; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: 129S1/SvImJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reduced female fertility ( J:143749 )

♀ • female mice produce fewer pups per litter and the time between litters is slightly longer than in control mice that do not express cre

decreased litter size ( J:143749 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:143749 )

N • despite reduced adiposity, mice exhibit normal lipolysis

decreased susceptibility to diet-induced obesity ( J:143749 )

• when fed a high fat diet, mice initially gain more weight than control mice but cease gaining weight after 2 to 3 weeks and over all weight gain is 41% of starting weight compared to 85% in control mice

decreased circulating glucose level ( J:143749 )

• when fed a standard or high fat diet

decreased circulating insulin level ( J:143749 )

• when fed a standard diet

decreased circulating leptin level ( J:143749 )

• when fed a standard or high fat diet

decreased circulating cholesterol level ( J:143749 )

• when fed a high fat diet

increased oxygen consumption ( J:143749 )

• when fed a standard or high fat diet, oxygen consumption in white adipose cells is increased compared to in control cells

improved glucose tolerance ( J:143749 )

• when fed a high fat diet

decreased adiponectin level ( J:143749 )

• when fed a standard or high fat diet

decreased liver triglyceride level ( J:143749 )

• when fed a standard diet, liver triglyceride levels are lower than in control mice

• however, mice fed a high fat diet exhibit normal liver steatosis and liver triglyceride levels

adipose tissue

decreased brown adipose tissue amount ( J:143749 )

• when fed a standard or high fat diet

decreased white fat cell number ( J:143749 )

• when fed a standard or high fat diet

decreased white fat cell size ( J:143749 )

• when fed a high fat diet

decreased total fat pad weight ( J:143749 )

• when fed a standard diet and more pronounced when fed a high fat diet

growth/size/body

increased lean body mass ( J:143749 )

• when fed a standard or high fat diet, mice are leaner than controls

decreased body weight ( J:143749 )

• when fed a standard diet, mice weight 18% less than control mice that do not express cre

decreased susceptibility to diet-induced obesity ( J:143749 )

• when fed a high fat diet, mice initially gain more weight than control mice but cease gaining weight after 2 to 3 weeks and over all weight gain is 41% of starting weight compared to 85% in control mice

behavior/neurological

decreased locomotor activity ( J:143749 )

• when fed a standard diet, mice are less active on a running wheel compared to control mice

• however, mice exhibit normal food intake

digestive/alimentary system

digestive/alimentary phenotype ( J:143749 )

N • despite reduced adiposity, mice exhibit normal lipid absorption

liver/biliary system

decreased liver triglyceride level ( J:143749 )

• when fed a standard diet, liver triglyceride levels are lower than in control mice

• however, mice fed a high fat diet exhibit normal liver steatosis and liver triglyceride levels