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Phenotypes Associated with This Genotype
Genotype
MGI:3829707
Allelic
Composition		 Igkctm1(IGKC)Mnz/Igkc+
Igk-Jtm1(CD4*)Mss/Igk-J+
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkctm1(IGKC)Mnz mutation (2 available); any Igkc mutation (9 available)
Igk-Jtm1(CD4*)Mss mutation (0 available); any Igk-J mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immunoglobulin light chain V-J recombination ( J:143876 )
• mice were bred to carry the two mutant alleles in trans
• a 2:1 skew in favor of expression of the Igk-Ctm1(IGKC)Mnz allele among immature and mature B cells suggests the CD4 knock-in allele causes a recombination defect

hematopoietic system
abnormal immunoglobulin light chain V-J recombination ( J:143876 )
• mice were bred to carry the two mutant alleles in trans
• a 2:1 skew in favor of expression of the Igk-Ctm1(IGKC)Mnz allele among immature and mature B cells suggests the CD4 knock-in allele causes a recombination defect

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory