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Phenotypes Associated with This Genotype
Genotype
MGI:3829652
Allelic
Composition
Flcntm1Btt/Flcntm1Btt
Tg(Cdh16-cre)91Igr/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flcntm1Btt mutation (0 available); any Flcn mutation (10 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die of kidney failure by 3 weeks of age (J:143922)
• in late stages degeneration, necrosis and hemorrhages are seen (J:143922)
• rapamycin treatment extends survival with some mice surviving more than 50 days (J:143922)
• die of kidney failure by 3 weeks of age (J:143922)
• in late stages degeneration, necrosis and hemorrhages are seen (J:143922)
• rapamycin treatment extends survival with some mice surviving more than 50 days (J:143922)

renal/urinary system
• seen in late stages of kidney failure (J:143922)
• seen in late stages of kidney failure (J:143922)
• extremely dilated tubules, predominantly originating from the collecting ducts (J:143922)
• extremely dilated tubules, predominantly originating from the collecting ducts (J:143922)
• atrophic, compressed glomeruli are seen (J:143922)
• atrophic, compressed glomeruli are seen (J:143922)
• hyperplastic areas with multiple layers of epithelial cells are seen along the inner surface of tubules (J:143922)
• hyperplastic areas with multiple layers of epithelial cells are seen along the inner surface of tubules (J:143922)
• kidney weight is increased 10 fold compared to controls (J:143922)
• kidney weight is increased 10 fold compared to controls (J:143922)
• some proximal tubules are highly to moderately dilated (J:143922)
• some proximal tubules are highly to moderately dilated (J:143922)
• develop bilateral polycystic kidneys (J:143922)
• develop bilateral polycystic kidneys (J:143922)
• by 3 weeks of age (J:143922)
• by 3 weeks of age (J:143922)

homeostasis/metabolism
• levels of blood urea nitrogen are increased over 10 fold compared to littermate controls (J:143922)
• levels of blood urea nitrogen are increased over 10 fold compared to littermate controls (J:143922)

tumorigenesis
• hyperplasia and renal cell carcinoma are seen by P18 (J:143922)
• cystic renal cell carcinoma is frequently seen in extremely enlarged kidneys (J:143922)
• hyperplasia and renal cell carcinoma are seen by P18 (J:143922)
• cystic renal cell carcinoma is frequently seen in extremely enlarged kidneys (J:143922)

cardiovascular system
• seen in late stages of kidney failure (J:143922)
• seen in late stages of kidney failure (J:143922)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory