Phenotypes Associated with This Genotype

Genotype
MGI:3829443

• Allelic Composition: Tcrb^tm5Slek/Tcrb^tm5Slek
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell receptor beta chain V(D)J recombination ( J:143738 )

• recombination of the Tcrb locus is inefficient

• 22% of alphabeta T cells have one allele of Tcrb that has failed to recombine compared to none in T cells from controls

• there is also decreased transcription of the germline sequence

hematopoietic system

abnormal T cell receptor beta chain V(D)J recombination ( J:143738 )

• recombination of the Tcrb locus is inefficient

• 22% of alphabeta T cells have one allele of Tcrb that has failed to recombine compared to none in T cells from controls

• there is also decreased transcription of the germline sequence