Phenotypes Associated with This Genotype

Genotype
MGI:3829419

• Allelic Composition: Il12rb1^tm1Jm/Il12rb1^tm1Jm; Tg(Rorc-EGFP)1Ebe/?
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal effector T cell morphology ( J:137020 )

• splenic Th-17 cells that have an alphabeta TCR and are GFP-positive are slightly decreased compared to controls

• the ratio of IL-17 producing cells to IL-10 producing cells among the GFP-positive T cell population is significantly decreased

immune system

abnormal effector T cell morphology ( J:137020 )

• splenic Th-17 cells that have an alphabeta TCR and are GFP-positive are slightly decreased compared to controls

• the ratio of IL-17 producing cells to IL-10 producing cells among the GFP-positive T cell population is significantly decreased