Phenotypes Associated with This Genotype

Genotype
MGI:3829045

• Allelic Composition: Mesp1^tm2(cre)Ysa/Mesp1⁺; Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal cardiac epithelial to mesenchymal transition ( J:143444 )

abnormal cardiac outflow tract development ( J:143444 )

• at E9.5 the outflow tract is significantly shorter compared to controls and at an obtuse angle to the right ventricle

• defects in endothelial to mesenchymal transformation and in cardiac neural crest invasion

• decreased proliferation of ISL1 expressing cells

abnormal heart morphology ( J:143444 )

• 75% of mice have heart defects, most of which are arterial pole abnormalities

persistent truncus arteriosus ( J:143444 )

• seen in 3 of 13 mutants

abnormal heart development ( J:143444 )

• decreased proliferation of ISL1 expressing cells in the second heart field

double outlet right ventricle ( J:143444 )

atrioventricular septal defect ( J:143444 )

• seen in 5 of 13 mutants

ventricular septal defect ( J:143444 )

• seen in 9 of 13 mutants

bicuspid aortic valve ( J:143444 )

• seen in 4 of 13 mutants