Phenotypes for Fgf8 Isl1 MGI:3829040 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Fgf8^tm1Mrc/Fgf8^tm2Moon Isl1^tm1(cre)Sev/Isl1⁺
Genetic Background	involves: 129S/Sv * Black Swiss * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8^tm1Mrc mutation (0 available); any Fgf8 mutation (25 available)
Fgf8^tm2Moon mutation (0 available); any Fgf8 mutation (25 available)
Isl1^tm1(cre)Sev mutation (1 available); any Isl1 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal cardiac epithelial to mesenchymal transition ( J:143444 )

• in explants no cells manage to successfully undergo endothelial to mesenchymal transformation

abnormal cardiac outflow tract development ( J:143444 )

• outflow tracts are short and abnormally angulated

abnormal conotruncal ridge morphology ( J:143444 )

• outflow tract cushions contain less cardiac jelly and fewer mesenchymal cells

• proximal outflow tract cushions are thinner and contain fewer cells while distal cushions are thinner but do not display a change in cell density

persistent truncus arteriosus ( J:143444 )

• all show type III PTA (the outflow tract is unseptated along its entire proximodstal extent)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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