Mouse Genome Informatics
ot
    Plp1tm1Frca/Y
B6.129-Plp1tm1Frca
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• at 1 month, optic nerves exhibit rare myelin whorls and some axons with loose myelin wraps unlike in wild-type mice (J:143305)
• at 6 months, mice exhibit more pronounced myelin whorls than at 3 months (J:143305)
• at 3 months, mice exhibit myelin membrane degeneration unlike in wild-type mice (J:143305)
• at 6 months, mice exhibit more pronounced myelin degeneration than at 3 months (J:143305)
• at 2 months, axonal degeneration is occasionally observed but the frequency of occurrence does not increase with age (J:143305)

behavior/neurological
N
• despite impaired coordination, mice exhibit normal grip strength and exploratory behavior (J:143305)
• at 3 and 6 months, the latency to fall off a rotarod is decreased compared to in wild-type mice (J:143305)

Mouse Models of Human Disease
OMIM IDRef(s)
Pelizaeus-Merzbacher Disease; PMD 312080 J:143305