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Phenotypes Associated with This Genotype
Genotype
MGI:3828308
Allelic
Composition
Plp1tm1Frca/Y
Genetic
Background
B6.129-Plp1tm1Frca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plp1tm1Frca mutation (0 available); any Plp1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 1 month, optic nerves exhibit rare myelin whorls and some axons with loose myelin wraps unlike in wild-type mice
• at 6 months, mice exhibit more pronounced myelin whorls than at 3 months
• at 2 months, axonal degeneration is occasionally observed but the frequency of occurrence does not increase with age
• at 3 months, mice exhibit myelin membrane degeneration unlike in wild-type mice
• at 6 months, mice exhibit more pronounced myelin degeneration than at 3 months

behavior/neurological
N
• despite impaired coordination, mice exhibit normal grip strength and exploratory behavior
• at 3 and 6 months, the latency to fall off a rotarod is decreased compared to in wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Pelizaeus-Merzbacher Disease; PMD 312080 J:143305


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory