Phenotypes Associated with This Genotype

Genotype
MGI:3828159

• Allelic Composition: Vgf^tm1Srjs/Vgf^tm1Srjs
• Genetic Background: B6.129-Vgf^tm1Srjs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:143370 )

N • unlike in mice with mixed background, locomotor activities are normal

abnormal contextual conditioning behavior ( J:143370 )

• mice exhibit decreased freezing in a contextual fear conditioning assay compared to wild-type mice

abnormal spatial learning ( J:143370 )

• in a Morris water maze, mice exhibit increased latency to reach a hidden platform and travel a greater distance compared to wild-type mice

• however, swim speed and cued learning are normal

nervous system

reduced long-term depression ( J:143370 )

• long term depression induced by low frequency stimulation is reduced compared to in wild-type mice

growth/size/body

increased lean body mass ( J:143370 )

• mice are lean compared to wild-type mice

decreased body size ( J:143370 )

adipose tissue

decreased total body fat amount ( J:143370 )

• fat stores are decreased compared to in wild-type mice

homeostasis/metabolism

abnormal metabolism ( J:143370 )

• mice are hypermetabolic compared to wild-type mice