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Phenotypes Associated with This Genotype
Genotype
MGI:3826827
Allelic
Composition		 Tg(Myh6-F2r)18Nmk/0
Genetic
Background		 involves: C57BL/6J
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♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
enlarged heart ( J:142990 )
• hearts grossly larger at 10 months than controls
increased heart weight ( J:142990 )
• age-dependent increase in heart weight/body weight ratio
dilated heart left ventricle ( J:142990 )
• lumenal area of the left ventricle is significantly increased
• free left ventricle wall thickness unchanged
abnormal cardiovascular system physiology ( J:142990 )
• left ventricular function is significantly reduced

growth/size/body
enlarged heart ( J:142990 )
• hearts grossly larger at 10 months than controls
increased heart weight ( J:142990 )
• age-dependent increase in heart weight/body weight ratio

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory