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Phenotypes Associated with This Genotype
Genotype
MGI:3826463
Allelic
Composition		 Rhohtm1Brak/Rhohtm1Brak
Tg(TcraTcrb)425Cbn/?
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhohtm1Brak mutation (0 available); any Rhoh mutation (13 available)
Tg(TcraTcrb)425Cbn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:143161 )
N
• no increase in DN4 cells observed
decreased CD4-positive, alpha-beta T cell number ( J:143161 )
• severely impaired generation of CD4+ cells

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:143161 )
• severely impaired generation of CD4+ cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory