Phenotypes Associated with This Genotype

Genotype
MGI:3823095

• Allelic Composition: Pou3f1^tm1Mejr/Pou3f1^tm1Mejr
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:34465 )

• all but 2-4% of animals die soon after birth; survivors live for a longer period

growth/size/body

decreased body size ( J:34465 )

• by P5, surviving mutants can be identified by smaller size

nervous system

abnormal sciatic nerve morphology ( J:34465 )

• nerve appears defective at P8 and P16

abnormal myelination ( J:34465 )

• no myelination of sciatic nerve is seen until second week postnatal whereas myelination is observed at P16 in wild-type

• myelination appears complete in adult nerves

• at P16, only larger axons are myelinated

• some Schwann cells show severely disrupted myelination, and fail to wrap myelin around the axon; other Schwann cells begin myelination before a 1:1 relation with axons is established

• sometimes myelination is seen in absence of axon

behavior/neurological

tremors ( J:34465 )

• by P5, surviving mutants exhibit tremors