Phenotypes Associated with This Genotype

Genotype
MGI:3822915

• Allelic Composition: Tg(Ly6a-SET/NUP214)2969Gcg/0
• Genetic Background: involves: FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased B cell apoptosis ( J:142938 )

• B220+ progenitor cells in the bone marrow exhibit increased apoptosis compared to in wild-type bone marrow

abnormal definitive hematopoiesis ( J:142938 )

• the number of B220+ progenitor cells is reduced 13% to 44% while the number of Sca1+ progenitor cells is increased 2- to 3.4-fold compared to in wild-type mice

• CD43^low/high B220+, Sca1+ and Sca1+ c-Kit+ progenitor cells accumulate in S-phase to a greater extent than in wild-type mice

• mice exhibit a 6-fold increase in the side population fraction after dual color Hoechst 33342 staining and FACS analysis compared to in wild-type mice

• the number of Sca1+ and Sca1+/c-Kit+ cells in the side fraction is increased 7.7- and 1.9-fold, respectively, compared to in wild-type mice

abnormal common myeloid progenitor cell morphology ( J:142938 )

• bone marrow cells produce 1.3- to 1.7-fold more colonies in methylcellulose compared to wild-type cells

• however, the colony forming ability of bone marrow cells in long-term culture-initiating cell assays is normal

• bone marrow cells exhibit a small increase in activity in a day 12 spleen colony-forming unit assay compared to wild-type cells

abnormal B cell differentiation ( J:142938 )

• the number of pre-B colony forming units in bone marrow is reduced 2-fold compared to in wild-type bone marrow

decreased pro-B cell number ( J:142938 )

• 3-fold

decreased leukocyte cell number ( J:142938 )

decreased lymphocyte cell number ( J:142938 )

• mice exhibit a 1.7- to 2.3-fold decrease in lymphocyte cell numbers compared to in wild-type mice

decreased pre-B cell number ( J:142938 )

• 3-fold

digestive/alimentary system

abnormal intestinal mucosa morphology ( J:142938 )

• mice develop moderate hyperplasia of the colonic mucosa unlike wild-type mice

abnormal stomach mucosa morphology ( J:142938 )

• despite an increase in apoptosis, mice exhibit hyperplasia of the stomach mucosa unlike wild-type mice

• proliferating low columnar to cuboidal epithelial cells replace parietal and chief cells

dilated gastric gland ( J:142938 )

• mice exhibit dilation of the glands with sloughing of the lining epithelia into the gland lumen unlike wild-type mice

stomach mucosa hyperplasia ( J:142938 )

• despite an increase in apoptosis, mice exhibit hyperplasia of the stomach mucosa unlike wild-type mice

neoplasm

neoplasm ( J:142938 )

N • mice exhibit normal tumorigenesis when infected with MOL4070A retrovirus

immune system

increased B cell apoptosis ( J:142938 )

• B220+ progenitor cells in the bone marrow exhibit increased apoptosis compared to in wild-type bone marrow

abnormal B cell differentiation ( J:142938 )

• the number of pre-B colony forming units in bone marrow is reduced 2-fold compared to in wild-type bone marrow

decreased pro-B cell number ( J:142938 )

• 3-fold

decreased leukocyte cell number ( J:142938 )

decreased lymphocyte cell number ( J:142938 )

• mice exhibit a 1.7- to 2.3-fold decrease in lymphocyte cell numbers compared to in wild-type mice

decreased pre-B cell number ( J:142938 )

• 3-fold

cellular

increased B cell apoptosis ( J:142938 )

• B220+ progenitor cells in the bone marrow exhibit increased apoptosis compared to in wild-type bone marrow

endocrine/exocrine glands

dilated gastric gland ( J:142938 )

• mice exhibit dilation of the glands with sloughing of the lining epithelia into the gland lumen unlike wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute leukemia		DOID:12603	OMIM:308960	J:142938