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Phenotypes Associated with This Genotype
Genotype
MGI:3822771
Allelic
Composition		 \Gt(ROSA)26Sortm1Sor/\Gt(ROSA)26Sor+
\Hesx1tm1(cre)Jpmb/\Hesx1tm1Icar
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (10 available); any Gt(ROSA)26Sor mutation (1097 available)
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (14 available)
Hesx1tm1Icar mutation (0 available); any Hesx1 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal telencephalon development ( J:135132 )
• telencepepahlic vesicle development is often asymmetric in embryos, with the right side being more severely affected
• very small telencephalic vesicle is sometimes observed at the 8-10 somite stage

vision/eye
abnormal optic vesicle formation ( J:135132 )
• development of optic vesicles is often asymmetric with right side more severely affected

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory