Phenotypes Associated with This Genotype

Genotype
MGI:3822755

• Allelic Composition: H2-T18^b/H2-T18^b; H2-T3^tm1Luc/H2-T3^tm1Luc
• Genetic Background: C57BL/6-H2-T3^tm1Luc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal intraepithelial T cell morphology ( J:142515 )

• IEL activation by low amounts of plate bound anti-CD3 is enhanced compared to controls

• differences at higher doses of anti-CD3 are not significant

• enhanced proliferation of IELs can be suppressed to wild-type levels when cultured in the presence of tumor cells bearing TL antigen

abnormal CD8-positive, alpha-beta intraepithelial T cell morphology ( J:142515 )

• colonic alpha-beta IELs expressing CD8-alpha homodimers have almost a 2-fold higher homeostatic proliferation rate in vivo

• enriched small intestine alpha-beta IEL have enhanced proliferation compared to controls in response to low amounts of plate bound anti-CD3

• when epithelial cells are removed from IEL culture, there is no longer a difference in the proliferative responses of IEL to anti-CD3

abnormal CD8-positive, gamma-delta intraepithelial T cell morphology ( J:142515 )

• colonic gamma-delta IELs expressing CD8-alpha homodimers have almost a 3-fold higher homeostatic proliferation rate in vivo

increased interferon-gamma secretion ( J:142515 )

• intestinal intraepithelial lymphocytes have enhanced IFN-gamma secretion in response to anti-CD3 stimulation

hematopoietic system

abnormal intraepithelial T cell morphology ( J:142515 )

• IEL activation by low amounts of plate bound anti-CD3 is enhanced compared to controls

• differences at higher doses of anti-CD3 are not significant

• enhanced proliferation of IELs can be suppressed to wild-type levels when cultured in the presence of tumor cells bearing TL antigen

abnormal CD8-positive, alpha-beta intraepithelial T cell morphology ( J:142515 )

• colonic alpha-beta IELs expressing CD8-alpha homodimers have almost a 2-fold higher homeostatic proliferation rate in vivo

• enriched small intestine alpha-beta IEL have enhanced proliferation compared to controls in response to low amounts of plate bound anti-CD3

• when epithelial cells are removed from IEL culture, there is no longer a difference in the proliferative responses of IEL to anti-CD3

abnormal CD8-positive, gamma-delta intraepithelial T cell morphology ( J:142515 )

• colonic gamma-delta IELs expressing CD8-alpha homodimers have almost a 3-fold higher homeostatic proliferation rate in vivo