Phenotypes Associated with This Genotype

Genotype
MGI:3822744

• Allelic Composition: Lama4^tm1Ktry/Lama4^tm1Ktry; Lama5^tm2Jhm/Lama5^tm2Jhm; Tg(ACTA1-cre)1Mll/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:142595 )

• mice die at around 3 months of age

nervous system

abnormal innervation pattern to muscle ( J:142595 )

• nuscle innervation is incomplete unlike in wild-type mice

abnormal neuromuscular synapse morphology ( J:142595 )

• both pre- and postsynaptic neuromuscular junction (NMJ) differentiation is delayed compared to in wild-type mice

• Schwann cell distribution is abnormal secondary to presynaptic defects in the NMJs

behavior/neurological

weakness ( J:142595 )

• mice are weaker than either single homozygous mice

growth/size/body

decreased body size ( J:142595 )

• mice are smaller than either single homozygous mice