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Phenotypes Associated with This Genotype
Genotype
MGI:3822743
Allelic
Composition		 Lama5tm1Jhm/Lama5tm1Jhm
Tg(ACTB-Lama5/LAMA1)1Jhm/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lama5tm1Jhm mutation (0 available); any Lama5 mutation (157 available)
Tg(ACTB-Lama5/LAMA1)1Jhm mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:142595 )
• unlike Lama5tm1Jhm homozygotes, mice several month before dieing from kidney disease

nervous system
abnormal neuromuscular synapse morphology ( J:142595 )
• maturation of postsynaptic neuromuscular junctions (NMJs) is delayed compared to in wild-type mice
• however, maturation of presynaptic NMJs is normal

renal/urinary system
abnormal renal/urinary system physiology ( J:142595 )
• mice die from kidney disease

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory