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Phenotypes Associated with This Genotype
Genotype
MGI:3822742
Allelic
Composition		 Lama5tm2Jhm/Lama5tm2Jhm
Tg(ACTA1-cre)1Mll/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lama5tm2Jhm mutation (0 available); any Lama5 mutation (157 available)
Tg(ACTA1-cre)1Mll mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuromuscular synapse morphology ( J:142595 )
• topological maturation of postsynaptic membrane at the neuromuscular junction (NMJ) is delayed by more than a week in the sternomastoid muscle compared to in wild-type mice
• both pre- and postsynaptic NMJ differentiation is delayed compared to in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory