Phenotypes Associated with This Genotype

Genotype
MGI:3822546

• Allelic Composition: Sirt3^tm1.1Cxd/Sirt3^tm1.1Cxd
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:142586 )

N • mice exhibit normal survival during the first year of life

cellular

abnormal cell physiology ( J:142586 )

• mouse embryonic fibroblasts (MEFs) exhibit a 30% reduction in ATP levels compared to wild-type cells

• heart, kidney and liver ATP levels are more than 50% decreased compared to in wild-type mice

• MEFs are insensitive to rotenone or hydrogen peroxide induced ATP reduction unlike wild-type cells

• however, MEF sensitivity to a cytochrome c oxidase

abnormal cellular respiration ( J:142586 )

• complex I activity is decreased compared to in wild-type mice

• however, complex II activity is normal

• cellular respirations in mouse embryonic fibroblasts is decreased compared to in wild-type cells