mortality/aging
• all mice die by 25 months
|
• fewer than expected mice are born
|
respiratory system
• 32% of mice develop lung adenocarcinoma
|
reproductive system
• female mice have fewer gametes than wild-type mice
|
• spindle abnormalities develop during meiosis
• however, oocytes progress through meiosis and arrest in metaphase II
|
• spindle abnormalities develop during meiosis
|
• mice possess fewer primordial or early growing follicles compared to in wild-type mice
• however, the number of secondary follicles is normal
|
• during ovulation oocytes remain trapped in the luteinizing granulose cells unlike in wild-type mice
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• oocytes of mice induced to superovulate are trapped under bursa and do not progress towards the fallopian tubes
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• superovulated females release no oocytes unlike similarly treated wild-type mice
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• despite normal cyclicity and mating behavior, mice are infertile
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• despite mating behavior, mice are infertile
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embryo
• only 28% of in vitro fertilized oocytes from Trp73tm1Mak homozygous females form blastocysts compared to 75% of wild-type zygotes, and blastocysts that do form arrest in early cleavage
|
neoplasm
• following treatment with DMBA mice develop tumors following a shorter latency than similarly treated wild-type mice
• however, sites of tumorigenesis following treatment with DMBA are the same as in similarly treated wild-type mice
|
• 18% of mice develop lymphoma that infiltrate more than one organ compared to 6% of wild-type mice that develop non-infiltrating lymphoma
|
• 14% of mice develop thymic lymphoma
|
• 9% of mice develop colon carcinoma in situ
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• 32% of mice develop lung adenocarcinoma
|
cellular
• female mice have fewer gametes than wild-type mice
|
• nocodozole treated lung fibroblasts exhibit increased loss of euploidy compared to similarly treated wild-type cells
• however, nocodozole treated thymic cells are euploid
|
polyploidy
(
J:142848
)
• nocodozole treated mouse embryonic fibroblasts exhibit an increase in 8N cells compared to similarly treated wild-type cells
|
• nocodozole treated mouse embryonic fibroblasts exhibit decreased mitotic arrest compared to similarly treated wild-type cells
|
• spindle abnormalities develop during meiosis
• however, oocytes progress through meiosis and arrest in metaphase II
|
• spindle abnormalities develop during meiosis
|
• only 28% of in vitro fertilized oocytes from Trp73tm1Mak homozygous females form blastocysts compared to 75% of wild-type zygotes, and blastocysts that do form arrest in early cleavage
|
nervous system
• at 10 weeks, the dentate gyrus is either completely missing or greatly reduced compared to in wild-type mice
|
homeostasis/metabolism
• following treatment with DMBA mice develop tumors following a shorter latency than similarly treated wild-type mice
• however, sites of tumorigenesis following treatment with DMBA are the same as in similarly treated wild-type mice
|
endocrine/exocrine glands
• mice possess fewer primordial or early growing follicles compared to in wild-type mice
• however, the number of secondary follicles is normal
|
• 14% of mice develop thymic lymphoma
|