Phenotypes Associated with This Genotype

Genotype
MGI:3822517

• Allelic Composition: Plk1^{Gt(RRR358)Byg}/Plk1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:142593 )

• at 50 - 70 weeks of age, tumor frequency is 27.5% compared to 9% in wild type controls

increased lymphoma incidence ( J:142593 )

• a significant proportion of the tumors are lymphomas that invade the lung and liver

increased lung carcinoma incidence ( J:142593 )

• most of the rest of the tumors are lung carcinomas

increased squamous cell carcinoma incidence ( J:142593 )

• seen in one case

increased sarcoma incidence ( J:142593 )

• one case of ovarian sarcoma was seen

cellular

aneuploidy ( J:142593 )

• splenocytes contain a higher percentage of aneuploidies

respiratory system

increased lung carcinoma incidence ( J:142593 )

• most of the rest of the tumors are lung carcinomas