Phenotypes Associated with This Genotype

Genotype
MGI:3822490

• Allelic Composition: Il15ra^tm1Wjl/Il15ra^tm1Wjl
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased NK cell number ( J:142570 )

• mice exhibit a reduction in splenic NK cells compared to in wild-type mice that is not as severe as in Il15ra^tm1Ama homozygotes

decreased CD8-positive, alpha-beta T cell number ( J:142570 )

• mice exhibit a reduction in CD8+ T cells compared to in wild-type mice that is not as severe as in Il15ra^tm1Ama homozygotes

decreased NK T cell number ( J:142570 )

• mice exhibit a reduction in NKT and thymic NKT cells compared to in wild-type mice that is not as severe as in Il15ra^tm1Ama homozygotes

decreased memory T cell number ( J:142570 )

• mice exhibit a reduction in CD44^highIL23beta+CD8+ memory T cells compared to in wild-type mice that is not as severe as in Il15ra^tm1Ama homozygotes

abnormal T cell physiology ( J:142570 )

• one month following infection with modified vaccinia Ankara virus, the number of IFN-gamma producing T cells is decreased compared to in similarly treated wild-type mice

decreased T cell proliferation ( J:142570 )

• TCR-activated CD8+ T cells stimulated with 5 ng/mL IL15 exhibit decreased proliferation compared to similarly treated wild-type cells

• memory and naive CD8+ T cells cultured with Il-21 plus IL15 (at either 50 ng/mL or 5 ng/mL) exhibit reduced proliferation compared to similarly treated wild-type cells

• however, treatment of TCR-activated CD8+ T cells with 50 ng/mL of IL15 induces normal T cell proliferation

hematopoietic system

decreased NK cell number ( J:142570 )

• mice exhibit a reduction in splenic NK cells compared to in wild-type mice that is not as severe as in Il15ra^tm1Ama homozygotes

decreased CD8-positive, alpha-beta T cell number ( J:142570 )

• mice exhibit a reduction in CD8+ T cells compared to in wild-type mice that is not as severe as in Il15ra^tm1Ama homozygotes

decreased NK T cell number ( J:142570 )

• mice exhibit a reduction in NKT and thymic NKT cells compared to in wild-type mice that is not as severe as in Il15ra^tm1Ama homozygotes

decreased memory T cell number ( J:142570 )

• mice exhibit a reduction in CD44^highIL23beta+CD8+ memory T cells compared to in wild-type mice that is not as severe as in Il15ra^tm1Ama homozygotes

abnormal T cell physiology ( J:142570 )

• one month following infection with modified vaccinia Ankara virus, the number of IFN-gamma producing T cells is decreased compared to in similarly treated wild-type mice

decreased T cell proliferation ( J:142570 )

• TCR-activated CD8+ T cells stimulated with 5 ng/mL IL15 exhibit decreased proliferation compared to similarly treated wild-type cells

• memory and naive CD8+ T cells cultured with Il-21 plus IL15 (at either 50 ng/mL or 5 ng/mL) exhibit reduced proliferation compared to similarly treated wild-type cells

• however, treatment of TCR-activated CD8+ T cells with 50 ng/mL of IL15 induces normal T cell proliferation

cellular

decreased T cell proliferation ( J:142570 )

• TCR-activated CD8+ T cells stimulated with 5 ng/mL IL15 exhibit decreased proliferation compared to similarly treated wild-type cells

• memory and naive CD8+ T cells cultured with Il-21 plus IL15 (at either 50 ng/mL or 5 ng/mL) exhibit reduced proliferation compared to similarly treated wild-type cells

• however, treatment of TCR-activated CD8+ T cells with 50 ng/mL of IL15 induces normal T cell proliferation