Phenotypes Associated with This Genotype

Genotype
MGI:3822449

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Tg(Cyp21a1-Apoe)619Fet/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating apolipoprotein E level ( J:130658 )

• mice have very reduced levels of Apoe (0-2 ug/ml) compared to wild-type plasma Apoe levels

abnormal lipid level ( J:130658 )

• plasma lipoprotein profiles are indistinguishable from Apoe-null nontransgenic littermates; LDL and VLDL distributions are similar to Apoe-deficient mice

increased circulating cholesterol level ( J:130658 )

• total plasma cholesterol levels (TPC) are about 580 mg/dl (mean TPC approx 302 mg/dl) compared to control mice (70-100 mg/dl); mice are hypercholesterolemic, similar to non-transgenic Apoe-deficient mice

cardiovascular system

decreased susceptibility to atherosclerosis ( J:130658 )

• almost no lesion staining is observed in mice between 7.5 months to >2.5 years of age, despite persistent hypercholesterolemia, but lesions are observed throughout aortas of nontransgenic Apoe-null littermates

• aorta cholesteryl ester (CE) depositions are reduced by 86% compared to nontransgenic Apoe-null littermates