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Phenotypes Associated with This Genotype
Genotype
MGI:3822323
Allelic
Composition
Tg(S100b-v-erbB)4496Waw/0
Trp53tm1Brd/Trp53+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J * DBA/2J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(S100b-v-erbB)4496Waw mutation (1 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (206 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice develop gliomas as in Cdkn2atm1Rdp/Cdkn2atm1Rdp Tg(S100b-v-erbB)4496Waw mice with loss of function of the wild-type Trp53 allele
• 80% of mice die within 6 months of high grade oligodendroglioma

mortality/aging
• 80% of mice die within 6 months of high grade oligodendroglioma

neoplasm
• mice develop gliomas as in Cdkn2atm1Rdp/Cdkn2atm1Rdp Tg(S100b-v-erbB)4496Waw mice with loss of function of the wild-type Trp53 allele
• 80% of mice die within 6 months of high grade oligodendroglioma

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
oligodendroglioma DOID:3181 J:82649


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory