Phenotypes Associated with This Genotype

Genotype
MGI:3822304

• Allelic Composition: Spint1^tm1Bug/Spint1^tm1Bug; St14^tm1Bug/St14^tm1Bug
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:142708 )

• double homozygotes born at near normal numbers

• die within the first day after birth

embryo

embryo phenotype ( J:142708 )

N • placentas normal, including labyrinth layer

N • no growth retardation

behavior/neurological

absent gastric milk in neonates ( J:142708 )

• 75% of double homozygous mutant pups lack milk spots in the stomach

integument

absent vibrissae ( J:142708 )

• absence of erupted whiskers

abnormal epidermal layer morphology ( J:142708 )

• reddish, wrinkled, dry

abnormal epidermis stratum corneum morphology ( J:142708 )

abnormal corneocyte morphology ( J:142708 )

• tightly packed immature corneocytes

thin epidermis ( J:142708 )

dry skin ( J:142708 )

reddish skin ( J:142708 )

wrinkled skin ( J:142708 )