Phenotypes Associated with This Genotype

Genotype
MGI:3822293

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Pecam1^{Gt(OST16303)Lex}/Pecam1^{Gt(OST16303)Lex}
• Genetic Background: B6.129-Apoe^tm1Unc Pecam1^{Gt(OST16303)Lex}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal aorta endothelium morphology ( J:142083 )

• Cx43 distribution at cell-cell junction shows less disruption than in single Apoe-deficient mice

atherosclerotic lesions ( J:142083 )

• major lesions are observed on lesser curvature of aortic arch in males and females with minor lesions found at branches of aortic arch

• lesions comprise around 14-16% of total aortic arch area in male and female mutants

• aortic lesions are observed in aortic sinus at level of aortic valve leaflets; lesions are about 27% of total aortal area

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:142083 )

N • cholesterol levels of double mutants on a Western or normal chow diet are not significantly different from diet-matched Apoe-null animals