Phenotypes for Igh MGI:3822282 MGI Mouse

abnormal B cell differentiation ( J:142069 )

decreased immature B cell number ( J:142069 )

• there is over a 30% decrease in the number of immature B cells (ie. fraction E cells) found in the bone marrow

decreased transitional stage B cell number ( J:142069 )

• there is about a 40% decrease in the number of transitional T3(A) B cells (i.e. "anergic" B cells) found in the spleen

increased early pro-B cell number ( J:142069 )

• there is a 60% increase in the number of early pro-B cells (i.e. fraction B cells) found in the bone marrow of mutant mice

decreased late pro-B cell number ( J:142069 )

• there is about a 40% decrease in the number of late pro-B cells (i.e. fraction D cells) compared to controls

decreased mature B cell number ( J:142069 )

• there is over a 40% decrease in the number of mature recirculating B cells found in the bone marrow

decreased B-1a cell number ( J:142069 )

• there is a over a 40% decrease in the number of B-1a B cells found in the peritoneal cavity

decreased follicular B cell number ( J:142069 )

• there is over a 40% decrease in the number of follicular B cells found in the spleen

increased marginal zone B cell number ( J:142069 )

• there is about a 40% increase in the number of marginal zone B cells found in the spleen

decreased IgM level ( J:142069 )

• mean antigen specific IgM levels are one-tenth of that observed in wild-type controls seven days after immunization with the T cell-independent antigen DEX

increased anti-nuclear antigen antibody level ( J:142069 )

• sera from 2 of 15 mice demonstrated ANA activity that was above background