Mouse Genome Informatics
tg
    Tg(Myh7-Ptpn11*Q79R)11Rbns/0
FVB.Cg-Tg(Myh7-Ptpn11*Q79R)11Rbns
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• 39% of mice die by 8 months of age

cardiovascular system
• postmortem
• at E16.5, mice exhibit ventricular noncompaction unlike in wild-type mice that persists postnatally without fibrosis
• cells in the noncompacted ventricle exhibit increased proliferation compared to in wild-type mice
• cells in the noncompacted ventricle and located at the boundaries of the muscular ventricular septum and atrioventricular cushion tissue exhibit increased proliferation compared to in wild-type mice

respiratory system

homeostasis/metabolism
• postmortem, mice display chronic left atria thrombi unlike in wild-type mice

muscle

Mouse Models of Human Disease
OMIM IDRef(s)
Noonan Syndrome 1; NS1 163950 J:123963