About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3822143
Allelic
Composition
Tg(Myh7-Ptpn11*Q79R)11Rbns/0
Genetic
Background
FVB.Cg-Tg(Myh7-Ptpn11*Q79R)11Rbns
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 39% of mice die by 8 months of age

cardiovascular system
• postmortem
• at E16.5, mice exhibit ventricular noncompaction unlike in wild-type mice that persists postnatally without fibrosis
• cells in the noncompacted ventricle exhibit increased proliferation compared to in wild-type mice
• cells in the noncompacted ventricle and located at the boundaries of the muscular ventricular septum and atrioventricular cushion tissue exhibit increased proliferation compared to in wild-type mice

respiratory system

homeostasis/metabolism
• postmortem, mice display chronic left atria thrombi unlike in wild-type mice

muscle

Mouse Models of Human Disease
OMIM ID Ref(s)
Noonan Syndrome 1; NS1 163950 J:123963


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory