Phenotypes Associated with This Genotype

Genotype
MGI:3822040

• Allelic Composition: H2-T23^tm2Cant/H2-T23^tm2Cant; Tg(Tcra2D2,Tcrb2D2)1Kuch/?
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD4-positive, alpha-beta T cell physiology ( J:142087 )

• CD4 T cells are highly susceptible to dose-dependent suppression by CD8 T regulatory cells in vitro

• this suppression is dependent on Fas ligand being expressed by the CD8 T regulatory cell

increased susceptibility to experimental autoimmune encephalomyelitis ( J:142087 )

• transfer of CD4 T cells into Rag2^-/^- Prf1^-/^- hosts initiates a progressive and lethal form of EAE that results in death from fulminant disease within 14?16 days after transfer

• co-transfer of CD8 T regulatory cells with mutant CD4 T cells prevents disease where as co-transfer of CD8 T regulatory cells with transgenic CD4 T cells not carrying the H2-T23 mutation fails to prevent disease

hematopoietic system

abnormal CD4-positive, alpha-beta T cell physiology ( J:142087 )

• CD4 T cells are highly susceptible to dose-dependent suppression by CD8 T regulatory cells in vitro

• this suppression is dependent on Fas ligand being expressed by the CD8 T regulatory cell