Phenotypes Associated with This Genotype

Genotype
MGI:3822013

• Allelic Composition: Dock7^mnlt/Dock7^mnlt
• Genetic Background: C57BL/6J-Dock7^mnlt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Dock7^mnlt/Dock7^mnlt mice exhibit a lightened coat color, a belly spot and hypopigmentation of extremities

behavior/neurological

behavior/neurological phenotype ( J:146458 )

N • homozygous mutant and wild type C57BL/6J mice exhibit similar locomotor activity; response in the tail-suspension test for depressive behavior; learning as measured by habituation of object exploration; working memory as measured using the Y maze; anxiety-like behavior in a light-dark transfer test; and preference for social familiarity/novelty

abnormal maternal behavior ( J:146458 )

♀ • homozygous mutant females are poor mothers, and their pups must be fostered to survive to weaning; this is not true of misty (Dock7^m) mothers

abnormal social investigation ( J:146458 )

• female moonlight mice show a tendency, though not statistically significant (P=0.0619), toward decreased social interaction

limbs/digits/tail

decreased digit pigmentation ( J:146458 )

• the distal extremities of the paws of homozygous mutant mice invariably lack pigment

non-pigmented tail tip ( J:146458 )

• variable; incompletely penetrant

pigmentation

diluted coat color ( J:146458 )

belly spot ( J:146458 )

• white spotting, variable in extent, may be present on the belly; penetrance of this phenotype is incomplete

abnormal skin pigmentation ( J:146458 )

• hypopigmentation of external genitalia

decreased digit pigmentation ( J:146458 )

• the distal extremities of the paws of homozygous mutant mice invariably lack pigment

non-pigmented tail tip ( J:146458 )

• variable; incompletely penetrant

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:146458 )

N • the bleeding time of homozygous moonlight mice is similar to that of normal controls, indicating normal function of platelet dense granules; this is in contrast to the prolonged bleeding time reported for misty (Dock7^m) homozygotes

immune system

immune system phenotype ( J:146458 )

N • in vivo cytotoxic efficiency of natural killer (NK) cells vs. target cells is normal

N • resistance of homozygous mutant mice to infection by mouse cytomegalovirus (MCMV), a measure of NK cell function, is similar to that of resistant C57BL/6J control mice as determined by survival and by viral clearance from the spleen at 5 days post infection

N • in vivo cytotoxic efficiency of T lymphocytes vs. target cells is normal

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:146458 )

N • homozygous moonlight mice are able to hear

vision/eye

vision/eye phenotype ( J:146458 )

N • homozygous moonlight mice can see

integument

diluted coat color ( J:146458 )

belly spot ( J:146458 )

• white spotting, variable in extent, may be present on the belly; penetrance of this phenotype is incomplete

abnormal skin pigmentation ( J:146458 )

• hypopigmentation of external genitalia

decreased digit pigmentation ( J:146458 )

• the distal extremities of the paws of homozygous mutant mice invariably lack pigment

non-pigmented tail tip ( J:146458 )

• variable; incompletely penetrant