Phenotypes Associated with This Genotype

Genotype
MGI:3821976

• Allelic Composition: Snap25^tm1.1Bark/Snap25^tm1.1Bark
• Genetic Background: B6.Cg-Snap25^tm1.1Bark

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:142096 )

• on days 2 and 4 of a Morris water maze test, mice exhibit a higher latency to navigate to the visible platform and longer swim distances compared to wild-type mice

• spatial learning deficits are more pronounced in female mice

increased anxiety-related response ( J:142096 )

• in an elevated plus maze, mice spend more time in closed arms than open arms compared to wild-type mice

increased thigmotaxis ( J:142096 )

• in a Morris water maze test

decreased locomotor activity ( J:142096 )

• mice exhibit reduced motility, locomotion and rearing compared to wild-type mice

seizures ( J:142096 )

• mice exhibit seizures but less frequently and at a later stage than those observed in Snap25^tm1Bark homozygotes

nervous system

seizures ( J:142096 )

• mice exhibit seizures but less frequently and at a later stage than those observed in Snap25^tm1Bark homozygotes

abnormal hippocampus CA3 region morphology ( J:142096 )

• in the stratum lucidum of CA3, 2 and 4 month old mice exhibit expanded mossy fibers that form large bundles and separate the synaptophysin+ nerve endings into island-like structures unlike in wild-type mice

• pathological changes are progressive with age

decreased paired-pulse facilitation ( J:142096 )

• at 0.2 Hz but not 0.5 Hz

growth/size/body

decreased body weight ( J:142096 )

• female mice weigh slightly less than wild-type mice

• however, male weights are normal