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Phenotypes Associated with This Genotype
Genotype
MGI:3821934
Allelic
Composition		 Cdkn2atm1Cjs/Cdkn2atm1Cjs
Gt(ROSA)26Sortm1.1(MYC/ERT2)Gev/Gt(ROSA)26Sortm1.1(MYC/ERT2)Gev
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Cjs mutation (5 available); any Cdkn2a mutation (59 available)
Gt(ROSA)26Sortm1.1(MYC/ERT2)Gev mutation (0 available); any Gt(ROSA)26Sor mutation (1062 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased cell proliferation ( J:142030 )
• tamoxifen treated mice exhibit increased cell proliferation in all tissues examined except colonic epithelium as in Gt(ROSA)26Sortm1.1(MYC/ESR1)Gev homozygotes
• tamoxifen treated mice exhibit colonic epithelium proliferation that is greater than in Gt(ROSA)26Sortm1.1(MYC/ESR1)Gev homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory