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Phenotypes Associated with This Genotype
Genotype
MGI:3821886
Allelic
Composition
Tg(CAG-LacZ,-ACVR1*,-EGFP)35-1Mis/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• by P30, limbs injected with adenovirus cre at P11 exhibit bony calluses encasing the tibia and fibula as well as fused with the pelvis and femur rendering hip, knee and ankle joints immobile unlike in similarly treated wild-type mice
• however, treatment of adenovirus cre exposed mice with LDN-193189, an inhibitor of BMP type I receptors, or dexamethasone reduces ectopic calcifications
• by P30, limbs injected with adenovirus cre at P11 exhibit reduced mobility including loss of passive flexion in the hip, knee and ankle under aesthesia unlike in similarly treated wild-type mice

muscle
• regardless of LDN-193189 treatment, limbs injected with adenovirus cre at P11 exhibit mononuclear cell infiltration and myocyte edema in tissues undergoing recombination unlike in similarly treated wild-type mice

immune system
• regardless of LDN-193189 treatment, limbs injected with adenovirus cre at P11 exhibit mononuclear cell infiltration and myocyte edema in tissues undergoing recombination unlike in similarly treated wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Fibrodysplasia Ossificans Progressiva; FOP 135100 J:142253


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory