Phenotypes Associated with This Genotype

Genotype
MGI:3821863

• Allelic Composition: Pcdhg^tm2Xzw/Pcdhg^tm2Xzw; Tg(Pax6-cre,GFP)2Pgr/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:142186 )

N • despite the reduction in several retinal cell types, the numbers of horizontal cells, photoreceptors and synapses in the inner plexiform layer are normal

abnormal Muller cell morphology ( J:142186 )

• the numbers of Muller glial cells is decreased 20% compared to in wild-type mice

decreased amacrine cell number ( J:142186 )

• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice

• the number of Pax6-amacrine cells in the central retina is reduced 58% compared to in wild-type mice

decreased retina ganglion cell number ( J:142186 )

• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice

• mice exhibit a 15% loss of Pou4f1+ retinal ganglion cells from the central retina compared to in wild-type mice

abnormal retina bipolar cell morphology ( J:142186 )

• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice

nervous system

abnormal Muller cell morphology ( J:142186 )

• the numbers of Muller glial cells is decreased 20% compared to in wild-type mice

decreased amacrine cell number ( J:142186 )

• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice

• the number of Pax6-amacrine cells in the central retina is reduced 58% compared to in wild-type mice

decreased retina ganglion cell number ( J:142186 )

• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice

• mice exhibit a 15% loss of Pou4f1+ retinal ganglion cells from the central retina compared to in wild-type mice

abnormal retina bipolar cell morphology ( J:142186 )

• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice

cellular

abnormal Muller cell morphology ( J:142186 )

• the numbers of Muller glial cells is decreased 20% compared to in wild-type mice