Phenotypes Associated with This Genotype

Genotype
MGI:3821760

• Allelic Composition: Igf1^tm2Arge/Igf1^tm2Arge
• Genetic Background: involves: 129S/SvEv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:142247 )

• only 11% of neonates survive

neonatal lethality, incomplete penetrance ( J:142247 )

• only 11% of neonates survive

reproductive system

infertility ( J:142247 )

growth/size/body

decreased body weight ( J:142247 )

• mice weigh 34% of wild-type

postnatal growth retardation ( J:142247 )

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:142247 )

• at P72, IGF1 serum levels are below detectable levels

skeleton

abnormal long bone epiphyseal plate proliferative zone ( J:142247 )

• the proliferative zone is half the size of the hypertrophic zone unlike in wild-type mice

decreased long bone epiphyseal plate size ( J:142247 )

• the proliferative zone and hypertrophic zone of the tibia growth plates are decreased compared to in wild-type mice