Phenotypes Associated with This Genotype

Genotype
MGI:3820657

• Allelic Composition: Plin2^tm1Itl/Plin2^tm1Itl
• Genetic Background: involves: 129S6/SvEvTac * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:142021 )

N • despite disruptions in eye physiology, eye morphology is normal

abnormal eye electrophysiology ( J:142021 )

• at 1 year of age, mice exhibit attenuated electroretinogram responses compared to wild-type mice affecting both a- and b-waves under scotopic conditions and b-waves under photopic conditions

delayed dark adaptation ( J:142021 )

• Background Sensitivity: delayed dark adaptation is more prominent on a mixed BALB/c background then on a mixed C57BL/6 background

homeostasis/metabolism

abnormal vitamin A metabolism ( J:142021 )

• under dark-adapted conditions, mice exhibit a decrease in all-trans-retinal but slower clearance of all-trans retinal and all-trans retinol compared to in wild-type mice results in a 20% increase in all-trans-retinal levels immediately after light illumination and a 40% increase 15 minutes after illumination

• newly formed retinyl esters assemble into more aggregates than in wild-type mice and these aggregates are highly mobile unlike in wild-type cells

• however, accumulation of A2E and iso-A2E is normal