Phenotypes Associated with This Genotype

Genotype
MGI:3820650

• Allelic Composition: Nfatc3^tm1Grc/Nfatc3^tm1Grc; Tg(Lck-cre)I57Jxm/0
• Genetic Background: involves: ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell apoptosis ( J:141917 )

• in culture, the initial number of double positive T cell undergoing apoptosis is greater than for wild-type cells

• however, the rate of apoptosis in vitro is normal

thymus hypoplasia ( J:141917 )

• the total number of thymocytes is reduced by half of wild-type

decreased thymocyte number ( J:141917 )

• the total number of thymocytes is reduced by half of wild-type

• the number of single positive T cells in the thymus is lower than in wild-type mice

• however, the number of double positive cells is normal

abnormal T cell differentiation ( J:141917 )

• T cell development is partially blocked after pre-TCR signaling and the DN4 population is reduced compared to in wild-type mice

increased double-negative T cell number ( J:141917 )

• mice exhibit an increase in double negative T cell compared to in wild-type mice up to stage DN4

decreased CD4-positive, alpha-beta T cell number ( J:141917 )

• in the thymus

decreased CD8-positive, alpha-beta T cell number ( J:141917 )

• in the thymus

lymph node hypoplasia ( J:141917 )

• the total number of inguinal lymph node cells is decreased by half of wild-type

hematopoietic system

increased T cell apoptosis ( J:141917 )

• in culture, the initial number of double positive T cell undergoing apoptosis is greater than for wild-type cells

• however, the rate of apoptosis in vitro is normal

thymus hypoplasia ( J:141917 )

• the total number of thymocytes is reduced by half of wild-type

decreased thymocyte number ( J:141917 )

• the total number of thymocytes is reduced by half of wild-type

• the number of single positive T cells in the thymus is lower than in wild-type mice

• however, the number of double positive cells is normal

abnormal T cell differentiation ( J:141917 )

• T cell development is partially blocked after pre-TCR signaling and the DN4 population is reduced compared to in wild-type mice

increased double-negative T cell number ( J:141917 )

• mice exhibit an increase in double negative T cell compared to in wild-type mice up to stage DN4

decreased CD4-positive, alpha-beta T cell number ( J:141917 )

• in the thymus

decreased CD8-positive, alpha-beta T cell number ( J:141917 )

• in the thymus

cellular

increased T cell apoptosis ( J:141917 )

• in culture, the initial number of double positive T cell undergoing apoptosis is greater than for wild-type cells

• however, the rate of apoptosis in vitro is normal

endocrine/exocrine glands

thymus hypoplasia ( J:141917 )

• the total number of thymocytes is reduced by half of wild-type

decreased thymocyte number ( J:141917 )

• the total number of thymocytes is reduced by half of wild-type

• the number of single positive T cells in the thymus is lower than in wild-type mice

• however, the number of double positive cells is normal