Phenotypes Associated with This Genotype

Genotype
MGI:3820409

• Allelic Composition: Gata1^{tm5(GATA3)Sho}/Gata1⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:47295 )

♀ • only two thirds of expected female mice survive into adulthood

lethality throughout fetal growth and development, incomplete penetrance ( J:47295 )

♀ • one third of female mice die after E15.5 of severe anemia

embryonic lethality during organogenesis, incomplete penetrance ( J:47295 )

♀ • some female mice die between E11.5 and E14.5

hematopoietic system

abnormal definitive hematopoiesis ( J:47295 )

♀ • at E15.5, most female mice exhibit an increase in circulating immature hematopoitic cells compared to in wild-type mice

anemia ( J:47295 )

♀ • one third of female mice die after E15.5 of severe anemia

decreased erythrocyte cell number ( J:47295 )

♀ • at E15.5, most female mice exhibit reduced total erythroid cells compared to in wild-type mice

embryo

pale yolk sac ( J:47295 )

♀ • at E14.6 and E16.5

integument

pallor ( J:47295 )

♀ • beyond E15.5, most female mice look pale