Phenotypes Associated with This Genotype

Genotype
MGI:3820284

• Allelic Composition: Reln^rl-od/Reln^rl-od
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:79979 )

• mice die by 13 - 18 days of age, 1 - 2 days after the appearance of a reeler like phenotype

behavior/neurological

tremors ( J:79979 )

abnormal motor coordination/balance ( J:79979 )

• when attempting to walk mice often fall on one side and crawl backwards

• reeler like phenotype first appears at 12 - 16 days of age

ataxia ( J:79979 )

• ataxic gait

decreased locomotor activity ( J:79979 )

nervous system

abnormal hippocampus morphology ( J:79979 )

• incomplete formation of the principal cell layers

abnormal dentate gyrus morphology ( J:79979 )

• bilaminated rather than trilaminated Timm staining pattern

inverted cerebral cortex lamination ( J:79979 )

• inversion of the principal neuronal layers in the neocortex

abnormal cerebellar Purkinje cell layer ( J:79979 )

• Purkinje cells cluster in the central part of the cerebellum

growth/size/body

decreased body weight ( J:79979 )

• weigh about 1g less than littermate controls at P15

postnatal growth retardation ( J:79979 )

• body weight gain curves deviate from controls by P5